Correction: A Novel Three-Filament Model of Force Generation in Eccentric Contraction of Skeletal Muscles
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In the Funding section, the grant number from the funder Austrian Science Fund (FWF) is missing. The grant number is: T 478-N13. The publisher apologizes for the error. open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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A Novel Three-Filament Model of Force Generation in Eccentric Contraction of Skeletal Muscles
We propose and examine a three filament model of skeletal muscle force generation, thereby extending classical cross-bridge models by involving titin-actin interaction upon active force production. In regions with optimal actin-myosin overlap, the model does not alter energy and force predictions of cross-bridge models for isometric contractions. However, in contrast to cross-bridge models, the...
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Muscle contraction and force regulation in skeletal muscle have been thought to occur exclusively through the relative sliding of and the interaction between the contractile filaments actin and myosin. While this two-filament sarcomere model has worked well in explaining the properties of isometrically and concentrically contracting muscle, it has failed miserably in explaining experimental obs...
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